Spatially defined immune cell “neighborhoods” distinguish TCRLBCL from cHL and DLBCL-NOS. The cellular composition together with the expression of PD-L1 and PD-1 is determined in small regions to construct tumor-immune “neighborhoods” throughout the section. These neighborhoods are then clustered into 7 clusters using K-mean clustering, which are used to visualize and compare the immunoarchitecture of different cases and different types of lymphoma. See Figure 4 in the article by Griffin et al that begins on page 1353.