Table 2.

Diagnostic Performance of the AORTAs Score in the Study Cohorts

Diagnostic Variable	Study Cohorts
	Derivation Cohort			Validation Cohorts
	(n=1848)			High Prevalence Cohort (n=1035)			Low Prevalence Cohort (n=447)
	AORTAs≥2	ADD≥2	P Value	AORTAs≥2	ADD≥2	P Value	AORTAs≥2	ADD≥2	P Value
Sensitivity	77.6% (71.8%–82.7%)	55.2% (48.7%–61.6%)	<0.001	54.1% (48.1%–60.5%)	34.8% (29.2%–40.8%)	<0.001	71.4% (56.7%–83.4%)	38.8% (25.2%–53.8%)	<0.001
Specificity	70.8% (68.5%–73%)	87.1% (85.3%–88.7%)	<0.001	75.9% (72.8%–78.8%)	84.5% (81.9%–87%)	<0.001	72.1% (67.4%–76.5%)	89.1% (85.6%–92%)	<0.001
LR+	2.66 (2.40–2.94)	4.26 (3.60–5.06)	<0.001	2.25 (1.89–2.67)	2.25 (1.77–2.86)	1.0	2.56 (2.02–3.25)	3.55 (2.26–5.58)	0.13
LR‐	0.32 (0.25–0.40)	0.52 (0.45–0.59)	<0.001	0.61 (0.52–0.70)	0.77 (0.70–0.85)	<0.001	0.40 (0.25–0.62)	0.69 (0.12–0.86)	0.009

95% CI in parentheses. ADD indicates aortic dissection detection; and LR, likelihood ratio.