Table 2.
Diagnostic Variable | Study Cohorts | ||||||||
---|---|---|---|---|---|---|---|---|---|
Derivation Cohort | Validation Cohorts | ||||||||
(n=1848) | High Prevalence Cohort (n=1035) | Low Prevalence Cohort (n=447) | |||||||
AORTAs≥2 | ADD≥2 | P Value | AORTAs≥2 | ADD≥2 | P Value | AORTAs≥2 | ADD≥2 | P Value | |
Sensitivity | 77.6% (71.8%–82.7%) | 55.2% (48.7%–61.6%) | <0.001 | 54.1% (48.1%–60.5%) | 34.8% (29.2%–40.8%) | <0.001 | 71.4% (56.7%–83.4%) | 38.8% (25.2%–53.8%) | <0.001 |
Specificity | 70.8% (68.5%–73%) | 87.1% (85.3%–88.7%) | <0.001 | 75.9% (72.8%–78.8%) | 84.5% (81.9%–87%) | <0.001 | 72.1% (67.4%–76.5%) | 89.1% (85.6%–92%) | <0.001 |
LR+ | 2.66 (2.40–2.94) | 4.26 (3.60–5.06) | <0.001 | 2.25 (1.89–2.67) | 2.25 (1.77–2.86) | 1.0 | 2.56 (2.02–3.25) | 3.55 (2.26–5.58) | 0.13 |
LR‐ | 0.32 (0.25–0.40) | 0.52 (0.45–0.59) | <0.001 | 0.61 (0.52–0.70) | 0.77 (0.70–0.85) | <0.001 | 0.40 (0.25–0.62) | 0.69 (0.12–0.86) | 0.009 |
95% CI in parentheses. ADD indicates aortic dissection detection; and LR, likelihood ratio.