Figure 1. The diagrams illustrate 2 types of 0.014‐inch stainless steel guidewires used in the present study.

Adenosine‐releasing guidewires are redesigns of 2 popular commercially approved wires (0.014‐inch stainless steel), which have been modified by increasing the coil spacing to 0.005 inches in the distal 15 cm to accommodate the hydrophilic‐drug polymer. In (A) the radiopaque platinum‐tungsten portion is incorporated in the mandrel and in (B) is in the 3 cm of tightly wound coil at the tip. C, A micrograph of the redesigned 0.005‐inch coils before coating. D, Micrograph of the 0.005‐inch coils after coating with the polyethylene glycol–silane primer layer, adenosine‐loaded hydrogel layer and diffusion‐barrier layer. PTFE indicates polytetrafluoroethylene.