Table 3.

Association Between VMS Over the Study and Combined Incident Fatal and Nonfatal CVD Events in SWAN (N=3083)

Variable	Model 1: HR (95% CI), P Value	Model 2: HR (95% CI), P Value
Persistent frequent VMS (>33% of attended visits with frequent VMS)*	1.98 (1.51–2.59), <0.0001	1.77 (1.33–2.35), <0.0001

For >33% of attended visits with frequent VMS: N=743, CVD events=99. Frequent VMS: VMS ≥6 days in the prior 2 weeks; missing covariate values imputed on the basis of mean levels. Model 1: adjusted for site, baseline age, race/ethnicity, and number of attended visits. Model 2: adjusted for model 1 covariates+baseline education, average financial strain, baseline menopause stage, average systolic blood pressure, average body mass index, average low‐density lipoprotein cholesterol, average triglycerides, average homeostatic model assessment insulin resistance, average physical activity, proportion of visits smoking, medication use (proportion of visits using blood pressure–lowering, lipid‐lowering, antidiabetic, or hormone therapy), and number of attended visits. CVD indicates cardiovascular disease; HR, hazard ratio; SWAN, Study of Women’s Health Across the Nation; and VMS, vasomotor symptoms.

^*Relative to ≤33% of attended visits with frequent VMS.