Table 2.
Cumulative Incidences of AMI After AIS for All Subgroups
| Variable | Cumulative Incidence, % (95% CI) | P Value* | ||||
|---|---|---|---|---|---|---|
| 1 y | 2 y | 3 y | 4 y | 5 y | ||
| Total all patients | 1.07 (0.89–1.27) | 1.29 (1.10–1.51) | 1.56 (1.35–1.80) | 1.81 (1.58–2.07) | 1.97 (1.72–2.26) | |
| Aged ≤70 y | 0.85 (0.65–1.11) | 1.05 (0.82–1.33) | 1.26 (1.00–1.56) | 1.42 (1.15–1.75) | 1.61 (1.30–1.98) | 0.0022 |
| Aged >70 y | 1.31 (1.03–1.63) | 1.56 (1.26–1.91) | 1.90 (1.57–2.29) | 2.25 (1.87–2.67) | 2.38 (1.98–2.83) | |
| Women | 1.08 (0.81–1.40) | 1.24 (0.96–1.59) | 1.47 (1.16–1.84) | 1.67 (1.33–2.07) | 1.85 (1.47–2.29) | 0.41 |
| Men | 1.06 (0.84–1.32) | 1.32 (1.07–1.61) | 1.63 (1.35–1.95) | 1.91 (1.60–2.26) | 2.06 (1.73–2.44) | |
| No history of hypertension | 0.58 (0.38–0.86) | 0.71 (0.48–1.02) | 0.89 (0.63–1.23) | 1.06 (0.76–1.43) | 1.23 (0.89–1.67) | <0.001 |
| History of hypertension | 1.30 (1.07–1.57) | 1.57 (1.31–1.86) | 1.88 (1.60–2.20) | 2.17 (1.86–2.52) | 2.33 (2.00–2.70) | |
| No history of diabetes mellitus | 0.82 (0.64–1.04) | 0.95 (0.76–1.18) | 1.18 (0.96–1.44) | 1.40 (1.16–1.69) | 1.51 (1.24–1.82) | <0.001 |
| History of diabetes mellitus | 1.56 (1.21–2.00) | 1.98 (1.58–2.46) | 2.35 (1.90–2.86) | 2.65 (2.17–3.20) | 2.65 (2.17–3.20) | |
| No history of CHD | 0.76 (0.61–0.94) | 1.00 (0.82–1.20) | 1.24 (1.04–1.46) | 1.46 (1.24–1.71) | 1.64 (1.39–1.92) | <0.001 |
| History of CHD | 4.12 (3.05–5.44) | 4.22 (3.13–5.54) | 4.78 (3.61–6.18) | 5.32 (4.07–6.79) | 5.32 (4.07–6.79) | |
| Stroke subtype | 0.001 | |||||
| Large‐artery atherosclerosis | 0.97 (0.71–1.30) | 1.13 (0.85–1.49) | 1.46 (1.13–1.85) | 1.82 (1.45–2.26) | 2.18 (1.73–2.71) | |
| Small‐vessel occlusion | 0.29 (9.12–0.61) | 0.53 (0.29–0.93) | 0.73 (0.43–1.17) | 0.84 (0.51–1.32) | 0.84 (0.51–1.32) | |
| Cardioembolism | 1.56 (1.13–2.10) | 1.84 (1.36–2.42) | 2.08 (1.57–2.69) | 2.31 (1.77–2.97) | 2.38 (1.82–3.04) | |
| Other determined | 0.79 (0.16–2.62) | 0.79 (0.16–2.62) | 1.18 (0.33–3.20) | 1.18 (0.33–3.20) | 1.18 (0.33–3.20) | |
| Undetermined | 1.40 (1.00–1.92) | 1.67 (1.23–2.23) | 1.95 (1.47–2.54) | 2.15 (1.63–2.77) | 2.23 (1.69–2.88) | |
| No symptomatic carotid artery disease | 0.98 (0.80–1.18) | 1.21 (1.01–1.43) | 1.47 (1.26–1.72) | 1.70 (1.46–1.97) | 1.84 (1.58–2.13) | 0.007 |
| Symptomatic carotid artery disease | 1.81 (1.18–2.67) | 1.97 (1.31–2.85) | 2.29 (1.57–3.22) | 2.73 (1.93–3.75) | 3.06 (2.16–4.20) | |
| No history of atrial fibrillation | 0.90 (0.72–1.10) | 1.11 (0.91–1.34) | 1.37 (1.15‐1.62) | 1.64 (1.39‐1.92) | 1.83 (1.55‐2.14) | 0.01 |
| History of atrial fibrillation | 1.71 (1.26‐2.29) | 1.96 (1.47‐2.57) | 2.29 (1.75‐2.94) | 2.47 (1.90‐3.14) | 2.53 (1.96‐3.22) | |
AIS indicates acute ischemic stroke; AMI, acute myocardial infarction; and CHD, coronary heart disease.
*
P values determined with the Grey test.