Table 4.

Differences in Fibrosis Percentage Assessed in Patients Treated With Sirolimus Versus CNI at Time of Baseline (1 Year) and at 3‐Year Follow‐Up

	Sirolimus (n=30)	CNI (n=40)	Difference (Sirolimus–CNI)	P Value	Age‐Adjusted Estimates (95% CI) (Sirolimus vs CNI)*	P Value
% fibrosis ±SD
Baseline	8.48±3.17	8.76±3.87	−0.28±1.63	0.75 †
Follow‐up	10.10±3.04	10.56±4.34	−0.46±1.72	0.62 †
Δ % fibrosis	1.62±4.67	1.80±5.31	−0.18±2.33	0.88 †	−0.37 (−1.62 to 0.89)	0.56
P value	0.07 ‡	0.04 ‡

CNI indicates calcineurin inhibitor.

^*β estimates of sirolimus conversion after adjustment for age at the time of heart transplant.

^† t test.

^‡Paired t test.