Table 3.
Incidence of Study End Points, According to the Underlying Heart Disease and ICD Indication
| Variable | SVA | P Value | Appropriate ICD Therapy | P Value | All‐Cause Death | P Value |
|---|---|---|---|---|---|---|
| ICM (n=2150) | 730 (34.0) | 658 (30.6) | 371 (17.3) | |||
| Primary prevention (n=1342) | 349 (26.0) | <0.001* | 310 (23.1) | <0.001* | 235 (17.5) | 0.686* |
| Secondary prevention (n=808) | 381 (47.2) | 348 (43.1) | 136 (16.8) | |||
| DCM (n=1166) | 355 (30.4) | 306 (26.2) | 167 (14.3) | |||
| Primary prevention (n=904) | 223 (24.8) | <0.001* | 187 (20.8) | <0.001* | 131 (14.6) | 0.656* |
| Secondary prevention (n=268) | 132 (49.4) | 119 (44.6) | 36 (13.4) | |||
| HCM (n=294) | 65 (22.1) | 49 (16.7) | 9 (3.1) | |||
| Primary prevention (n=228) | 38 (16.7) | <0.001* | 25 (10.1) | <0.001* | 5 (2.2) | 0.108* |
| Secondary prevention (n=66) | 27 (40.9) | 26 (39.4) | 4 (6.1) | |||
| VHD (n=119) | 49 (41.2) | 43 (36.1) | 19 (16) | |||
| Primary prevention (n=53) | 17 (33.1) | 0.071 | 16 (30.2) | 0.226* | 8 (15.1) | 0.816* |
| Secondary prevention (n=66) | 32 (48.5) | 27 (40.9) | 11 (16.7) | |||
| ARVC (n=71) | 31 (43.7) | 27 (38) | 1 (1.4) | |||
| Primary prevention (n=22) | 7 (31.8) | 0.178* | 6 (27.3) | 0.211* | 1 (4.5) | 0.310* |
| Secondary prevention (n=49) | 24 (49) | 21 (42.9) | 0 (0) | |||
| LQTS (n=43) | 8 (18.6) | 5 (11.6) | 1 (2.3) | |||
| Primary prevention (n=4) | 0 (0) | 0.424* | 0 (0) | 0.598* | 0 (0) | 0.746* |
| Secondary prevention (n=39) | 8 (20.5) | 5 (12.8) | 1 (2.6) | |||
| BS (n=143) | 13 (9.1) | 10 (7) | 1 (0.7) | |||
| Primary prevention (n=110) | 5 (4.5) | 0.002* | 3 (2.7) | 0.001* | 1 (0.9) | 0.583* |
| Secondary prevention (n=33) | 8 (24.2) | 7 (21.2) | 0 (0) | |||
| ACHD (n=60) | 23 (38.3) | 19 (31.7) | 5 (8.3) | |||
| Primary prevention (n=37) | 11 (29.7) | 0.082* | 8 (21.6) | 0.034* | 3 (8.1) | 0.936* |
| Secondary prevention (n=23) | 12 (52.2) | 11 (47.8) | 2 (8.7) |
Data are given as number (percentage). ACHD indicates adult congenital heart disease; ARVC, arrhythmogenic right ventricular cardiomyopathy; BS, Brugada syndrome; DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy; ICD, implantable cardioverter‐defibrillator; ICM, ischemic cardiomyopathy; LQTS, long‐QT syndrome; SVA, sustained ventricular arrhythmia; and VHD, valvular heart disease.
*
Comparison of the proportion of primary vs secondary prevention patients within the same cardiomyopathy subgroup.