. 2020 Dec 21;10(1):e018777. doi: 10.1161/JAHA.120.018777

Table 3.

T2* Values at Baseline and With MH in Control and CHD Subjects. Values Listed by CHD Subgroup as Well

	Control N=20	CHD N=24	LSOL N=15	RSOL N=2	TGA N=7	P Value ⁺
GA scan, wks Mean, SD	33.9 (33.6, 34.4)	33.8 (33.4, 34.2)	33.6 (33.2, 34.1)	34.1 (32.1, 36.2)	34.2 (33.5, 34.9)	0.64
EFW, g Mean, SD	2268.8 (2150.7, 2386.8)	2283.7 (2144.1, 2423.4)	2161.7 (2020.5, 2302.9)	2324.5 (1860.7, 2788.3)	2534.7 (2257.6, 2811.6)	0.86
TBV, mL Mean, SD	262.4 (245.0, 279.8)	238.2 (224.6, 251.9)	235.1 ^‡ (215.2, 252.7)	256.3 (215.2, 252.7)	241.6 (214.7, 259.3)	0.04
T2* base, ms Mean, 95% CI	99.7 (93.0, 106.4)	84.8 (78.9, 90.7)	84.5 ^‡ (77.4, 91.6)	81.6 (65.0, 98.2)	86.3 ^‡ (70.6, 102.0)	0.002
T2* MH, ms Mean, 95% CI	99.5 (94.1, 104.8)	88.9 ^§ (81.4, 96.5)	87.4 (77.3, 97.5)	84.8 (84.7, 85.0)	93.6 ^§ (79.9, 107.2)	0.06
T2* change, ms Mean, 95% CI	−0.2 (−7.3, 6.8)	4.2 (0.5, 7.8)	2.9 (−2.4, 8.1)	3.2 (−13.2, 19.7)	7.2 (4.6, 9.8)	0.1

Control

N=20

CHD

N=24

LSOL

N=15

RSOL

N=2

TGA

N=7

P Value ⁺

GA scan, wks

Mean, SD

33.9

(33.6, 34.4)

33.8

(33.4, 34.2)

33.6

(33.2, 34.1)

34.1

(32.1, 36.2)

34.2

(33.5, 34.9)

0.64

EFW, g

Mean, SD

2268.8

(2150.7, 2386.8)

2283.7

(2144.1, 2423.4)

2161.7 (2020.5, 2302.9)

2324.5 (1860.7, 2788.3)

2534.7 (2257.6, 2811.6)

0.86

TBV, mL

Mean, SD

262.4

(245.0, 279.8)

238.2

(224.6, 251.9)

235.1 ^‡

(215.2, 252.7)

256.3

(215.2, 252.7)

241.6

(214.7, 259.3)

0.04

T2* base, ms

Mean, 95% CI

99.7

(93.0, 106.4)

84.8

(78.9, 90.7)

84.5 ^‡

(77.4, 91.6)

81.6

(65.0, 98.2)

86.3 ^‡

(70.6, 102.0)

0.002

T2* MH, ms

Mean, 95% CI

99.5

(94.1, 104.8)

88.9 ^§

(81.4, 96.5)

87.4

(77.3, 97.5)

84.8

(84.7, 85.0)

93.6 ^§

(79.9, 107.2)

0.06

T2* change, ms

Mean, 95% CI

−0.2

(−7.3, 6.8)

4.2

(0.5, 7.8)

2.9

(−2.4, 8.1)

3.2

(−13.2, 19.7)

7.2

(4.6, 9.8)

0.1

CHD indicates congenital heart disease; EFW, estimated fetal weight; GA, gestational age; LSOL, left‐sided obstructive lesion; MH, maternal hyperoxia; RSOL, right‐sided obstructive lesion; TBV, total brain volume; and TGA, transposition of the great arteries.

^⁺

P value represents comparison between control and CHD group using linear regression with adjustment for gestational age at scan and fetal sex.

^{^‡}

P value represents comparison between control group and each subtype of congenital heart disease using a linear regression model with adjustment for gestational age at scan. Those with the symbol are significantly different from the control group (P<0.05).

^{^§}

Paired t test within each group, symbol denotes significant change of T2* from baseline to MH (P<0.05).