Figure 4. Gastrocnemius perfusion and receptor for advanced glycation end products (RAGE) staining.

(A) Individual responses in uptake of ²⁰¹Tl in gastrocnemius muscle from the nonischemic limb from baseline to final imaging for IgG treated (orange) and anti‐RAGE antibody (CR‐3) treated pigs (gray) and percentage change from baseline to final imaging. Orange bar, IgG treated; gray bar, CR‐3 treated. (B) Immunostained sections of gastrocnemius muscle taken at necropsy from nondiabetic, IgG, and CR‐3 treated diabetic pigs. Red arrows point to the red‐brown staining for RAGE in arterioles. %ID indicates percentage injected dose.