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. 2020 Dec 29;10(1):e019685. doi: 10.1161/JAHA.120.019685

Figure 2. ExoCDNF restores the calcium transient in hiPSC‐dCM perturbed by TG treatment, and wortmannin abrogates this beneficial effect of CDNF.

Figure 2

Groups: Control, TG, TG+CDNF, and TG+CDNF+wortmannin (representative traces in A). B, ΔSpike (average of 20 peaks for each experiment) represents the difference between the calcium level in a specific top peak in relation to the previous lower peak (see the inset). The values are expressed as means±SEM with 1‐way ANOVA followed by Bonferroni post hoc test. Each experiment represents the number of hiPSC‐dCM cultures tested. *P<0.01 vs control; @ P<0.01 vs TG and # P<0.01 vs CDNF+TG. CDNF indicates cerebral dopamine neurotrophic factor; hiPSC‐dCM, iPSC‐dCM, human induced pluripotent stem cells differentiated into cardiomyocytes; and TG, thapsigargin.