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. 2020 Dec 29;10(1):e019685. doi: 10.1161/JAHA.120.019685

Figure 5. ExoCDNF reduces cardiac mitochondrial impairment induced by I/R and wortmannin abrogates CDNF beneficial effects.

Figure 5

A, ADP‐stimulated complex I respiration; (B and C) ATP production; (D and E) Mitochondrial swelling; (F) Complex IV and maximal uncoupled oxygen respiration; (G and H) Mitochondrial transmembrane potential (ΔΨ); and (I and J) Reactive oxygen species (ROS) production. Groups: No‐I/R, I/R, preCDNF, postCDNF and preCDNF+Wortmannin, and postCDNF+Wortmannin. (Wortmannin 0.3 µmol/L). * P<0.05 vs I/R; @ P<0.05 vs No‐I/R; & P<0.05 vs preCDNF and # P<0.05 vs postCDNF. Number in each column is n of hearts. The data were expressed as means±SEM, with 1‐way ANOVA followed by Bonferroni post hoc tests. CDNF indicates cerebral dopamine neurotrophic factor; CTRL, control; and I/R, ischemia/reperfusion.