Figure 8. CDNF, but not CDNF‐ΔKTEL, protect in vivo the hearts of rats subjected to I/R.

CDNF or CDNF‐ΔKTEL were administered intraperitoneally (IP) after ischemia and before reperfusion and the infarct areas were evaluated. A, Representative images of the heart sections where the red regions represent the area at‐risk areas (TTC stained), the white regions represent the infarct areas, and the blue, nonaffected regions (Evans‐blue). B, Quantitative analysis of hearts showed a significant reduction (P<0.01, vs I/R) in the percentage of white/white+red areas of the hearts. The data were expressed as means±SEM of 7 hearts. With 1‐way ANOVA followed by Bonferroni post hoc tests. CDNF indicates cerebral dopamine neurotrophic factor; IA/AAR, infarct area/area at risk; I/R, ischemia/reperfusion; and TTC, triphenyltetrazolium chloride.