Table 4.
Performance Characteristics of Prior Safe Contrast Limit Equations 5*Weight/Creatinine and 2*CrCl and New Multivariate Models
| Safe Contrast Limit Equation | |||||
|---|---|---|---|---|---|
|
5*Weight/Creatinine (95% CI) |
2*CrCl | Full Model | Pragmatic Full Model | Pragmatic Minimum Model | |
| Average Calculated Contrast Limit | 427.7 mL | 151.0 mL | 367.6 mL | 327.0 mL | 299.3 mL |
| Sensitivity, % |
12.7 (10.0–16.0) |
73.8 (69.6–77.6) |
70.3 (66.0–74.3) |
63.1 (58.7–67.4) |
59.6 (55.1–64.0) |
| Specificity, % |
94.8 (94.1–95.4) |
39.1 (37.8–40.5) |
75.9 (74.7–77.1) |
75.6 (74.3–76.8) |
73.7 (72.4–74.5) |
| Accuracy, % | 53.7 | 56.5 | 73.1 | 69.3 | 66.6 |
|
Calibration HL P value |
<0.05 | <0.05 | 0.14 | 0.11 | 0.10 |
Full, pragmatic full, and pragmatic minimum model safe contrast equations are presented in Figure 3. For these equations, tolerated AKI rate was set to 10%. CrCl indicates creatinine clearance; HL, Hosmer–Lemeshow test (P>0.1 is appropriately calibrated; P<0.05 is miscalibrated).