Table 2.
Correlation of SARS-CoV-2 mutations with pathogenicity.
Location/Source | SARS-CoV-2 Genome Variation | Associated Phenotypic Changes | Ref. |
---|---|---|---|
Various Genome Sequences Database (Such As Gisaid Database) Analyzing | p.614(Asp to Gly) in S (Missense) | Higher fatality rate | [51] |
p.367(Val to Phe) in RBD of S (Missense) p.436(Trp to Arg) in RBD of S (Missense) p.364(Asp to Tyr) in RBD of S (Missense) |
Higher infectivity (higher affinity to human ACE2 receptors) | [52] | |
p.614(Asp to Gly) in S (Missense) | Higher infectivity | [52] | |
p.475(Ala to Val) in RBD of S (Missense) p.452(Leu to Arg) in RBD of S (Missense) p.483(Val to Ala) in RBD of S (Missense) p.490(Phe to Leu) in RBD of S (Missense) |
Resistant to multiple neutralizing antibodies | [52] | |
p.408(Arg to Ile) in RBD of S (Missense) p.455(Leu to Tyr) in RBD of S (Missense) p.486(Phe to Leu) in RBD of S (Missense) p.493(Gln to Asn) in RBD of S (Missense) p.498(Gln to Tyr) in RBD of S (Missense) p.501(Asn to Thr) in RBD of S (Missense) p.930(Ala to Val) in heptad repeat 1 (HR1) domain of S (Missense) p.936(Asp to Tyr) in heptad repeat 1 (HR1) domain of S (Missense) |
Reducing stability of spike proteins | [53] | |
p.3691 in NSP6 p.9659 in ORF-10 |
Reducing the stability of the proteins structures | [54] | |
8782C > T in ORF-1ab (Synonymous Mutation) 28144T > C in ORF-8 (Missense) 29095C > T in N (Synonymous Mutation) |
Potential Effects On Transmission and Severity of COVID-19 | [23] | |
Singapore | Elimination Of ORF8 (Deletion Of 382 nt) | Attenuated Phenotype | [43] |
During Passaging Virus in Vero-E6 Cells | 15-30 nt Deletion in S1/S2 Junction Region | Attenuated Phenotype | [49] |
China | 23403A > G in S (Missense) 23902A > C in S (Missense) 23607A > A in S (Missense) 22303T > G and 22301A > C in S (Missense) 27775T > C, 27776T > G, And 27777G > A in S (Missense) 22205G > C in S (Missense) |
Strengthen Phenotype | [47] |