Table 2.

Correlation of SARS-CoV-2 mutations with pathogenicity.

Location/Source	SARS-CoV-2 Genome Variation	Associated Phenotypic Changes	Ref.
Various Genome Sequences Database (Such As Gisaid Database) Analyzing	p.614(Asp to Gly) in S (Missense)	Higher fatality rate	[51]
	p.367(Val to Phe) in RBD of S (Missense) p.436(Trp to Arg) in RBD of S (Missense) p.364(Asp to Tyr) in RBD of S (Missense)	Higher infectivity (higher affinity to human ACE2 receptors)	[52]
	p.614(Asp to Gly) in S (Missense)	Higher infectivity	[52]
	p.475(Ala to Val) in RBD of S (Missense) p.452(Leu to Arg) in RBD of S (Missense) p.483(Val to Ala) in RBD of S (Missense) p.490(Phe to Leu) in RBD of S (Missense)	Resistant to multiple neutralizing antibodies	[52]
	p.408(Arg to Ile) in RBD of S (Missense) p.455(Leu to Tyr) in RBD of S (Missense) p.486(Phe to Leu) in RBD of S (Missense) p.493(Gln to Asn) in RBD of S (Missense) p.498(Gln to Tyr) in RBD of S (Missense) p.501(Asn to Thr) in RBD of S (Missense) p.930(Ala to Val) in heptad repeat 1 (HR1) domain of S (Missense) p.936(Asp to Tyr) in heptad repeat 1 (HR1) domain of S (Missense)	Reducing stability of spike proteins	[53]
	p.3691 in NSP6 p.9659 in ORF-10	Reducing the stability of the proteins structures	[54]
	8782C > T in ORF-1ab (Synonymous Mutation) 28144T > C in ORF-8 (Missense) 29095C > T in N (Synonymous Mutation)	Potential Effects On Transmission and Severity of COVID-19	[23]
Singapore	Elimination Of ORF8 (Deletion Of 382 nt)	Attenuated Phenotype	[43]
During Passaging Virus in Vero-E6 Cells	15-30 nt Deletion in S1/S2 Junction Region	Attenuated Phenotype	[49]
China	23403A > G in S (Missense) 23902A > C in S (Missense) 23607A > A in S (Missense) 22303T > G and 22301A > C in S (Missense) 27775T > C, 27776T > G, And 27777G > A in S (Missense) 22205G > C in S (Missense)	Strengthen Phenotype	[47]