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. 2021 Mar 13;154:104831. doi: 10.1016/j.micpath.2021.104831

Table 2.

Correlation of SARS-CoV-2 mutations with pathogenicity.

Location/Source SARS-CoV-2 Genome Variation Associated Phenotypic Changes Ref.
Various Genome Sequences Database (Such As Gisaid Database) Analyzing p.614(Asp to Gly) in S (Missense) Higher fatality rate [51]
p.367(Val to Phe) in RBD of S (Missense)
p.436(Trp to Arg) in RBD of S (Missense)
p.364(Asp to Tyr) in RBD of S (Missense)
Higher infectivity (higher affinity to human ACE2 receptors) [52]
p.614(Asp to Gly) in S (Missense) Higher infectivity [52]
p.475(Ala to Val) in RBD of S (Missense)
p.452(Leu to Arg) in RBD of S (Missense)
p.483(Val to Ala) in RBD of S (Missense)
p.490(Phe to Leu) in RBD of S (Missense)
Resistant to multiple neutralizing antibodies [52]
p.408(Arg to Ile) in RBD of S (Missense)
p.455(Leu to Tyr) in RBD of S (Missense)
p.486(Phe to Leu) in RBD of S (Missense)
p.493(Gln to Asn) in RBD of S (Missense)
p.498(Gln to Tyr) in RBD of S (Missense)
p.501(Asn to Thr) in RBD of S (Missense)
p.930(Ala to Val) in heptad repeat 1 (HR1) domain of S (Missense)
p.936(Asp to Tyr) in heptad repeat 1 (HR1) domain of S (Missense)
Reducing stability of spike proteins [53]
p.3691 in NSP6
p.9659 in ORF-10
Reducing the stability of the proteins structures [54]
8782C > T in ORF-1ab (Synonymous Mutation)
28144T > C in ORF-8 (Missense)
29095C > T in N (Synonymous Mutation)
Potential Effects On Transmission and Severity of COVID-19 [23]
Singapore Elimination Of ORF8 (Deletion Of 382 nt) Attenuated Phenotype [43]
During Passaging Virus in Vero-E6 Cells 15-30 nt Deletion in S1/S2 Junction Region Attenuated Phenotype [49]
China 23403A > G in S (Missense)
23902A > C in S (Missense)
23607A > A in S (Missense)
22303T > G and 22301A > C in S (Missense)
27775T > C, 27776T > G, And 27777G > A in S (Missense)
22205G > C in S (Missense)
Strengthen Phenotype [47]