Table 2.
Negative binomial regression analysis of the association between osmolality adjusted maternal BPA exposure divided into tertiles and the incidence rate ratio (IRR) and 95% confidence intervals (CI 95%) of ADHD-score in boys and girls at 2 and 5 years of age
| Osmolality adjusted BPA (ng/mL) |
Adjusteda IRR (CI 95%) All (N = 654) |
Adjusteda IRR (CI 95%) Boys (N = 347) | Adjusteda IRR (CI 95%) Girls (N = 307) |
| ASD-score at 2 years | |||
| 1th tertile (≤0.87) | Reference | Reference | Reference |
| 2nd tertile (0.88–1.96) | 0.87 (0.71–1.07) | 0.85 (0.65–1.10) | 0.89 (0.64–1.24) |
| 3rd tertile (≥ 1.97) | 1.02 (0.84–1.24) | 1.08 (0.84–1.39) | 0.91 (0.66–1.25) |
| p-trendb | 0.80 | 0.48 | 0.54 |
| Osmolality adjusted BPA (ng/mL) |
Adjusteda IRR (CI 95%) All (N = 425) |
Adjusteda IRR (CI 95%) Boys (N = 223) | Adjusteda IRR (CI 95%) Girls (N = 202) |
| ASD-score 5 years | |||
| 1st tertile (≤0.87) | Reference | Reference | Reference |
| 2nd tertile (0.88–1.96) | 1.13 (0.89–1.42) | 1.09 (0.80–1.51) | 1.18 (0.58–5.54) |
| 3rd tertile (≥ 1.97) | 1.23 (0.98–1.53) | 1.20 (0.88–1.63) | 1.29 (0.93–1.78) |
| p-trendb | 0.07 | 0.24 | 0.13 |
| Osmolality adjusted BPA (ng/mL) |
Adjusteda IRR (CI 95%) All (N = 425) |
Adjusteda IRR (CI 95%) Boys (N = 223) | Adjusteda IRR (CI 95%) Girls (N = 202) |
| ADHD-score at 5 years | |||
| 1st tertile (≤0.87) | Reference | Reference | Reference |
| 2nd tertile (0.88–1.96) | 0.96 (0.76–1.22) | 0.88 (0.66–1-17) | 1.11 (0.75–1.65) |
| 3rd tertile (≥ 1.97) | 1.08 (0.86–1.35) | 0.98 (0.75–1.30) | 1.26 (0.87–1.85) |
| p-trendb | 0.86 | 0.43 | 0.76 |
aAnalyses adjusted for maternal education, maternal age, pre-pregnancy BMI, child age at evaluation, parity. The sex-combined analyses were additionally adjusted for child sex
bTrend across tertiles tested by inserting the tertile osmolality adjusted BPA as an ordinal indicator variable (0,1,2)
* P-value < 0.05