Table 5.
Multiple logistic regression analysis of the association between osmolality adjusted maternal BPA exposure divided into tertiles and as continuous ln-transformed and the odds ratio (OR) and 95% confidence intervals (CI 95%) of an ADHD-score ≥ 75% compared to < 75% (reference) and ≥ 90th percentile compared to <90th percentile (reference) in boys and girls at 5 years of age
| Osmolality adjusted BPA (ng/mL) | All chidren (N = 109/316) Adjusteda OR (CI 95%) |
Boys (N = 66/157) Adjusteda OR (CI 95%) |
Girls (N = 43/159) Adjusteda OR (CI 95%) |
|---|---|---|---|
| ADHD-score 5 years ≥ 75th percentile | |||
| 1st tertile (≤0.87) | Reference | Reference | reference |
| 2nd tertile (0.88–1.96) | 0.81 (0.45–1.45) | 0.80 (0.37–1-73) | 0.88 (0.36–2.20) |
| 3rd tertile (≥ 1.97) | 1.09 (0.64–1.87) | 1.06 (0.51–2.17) | 1.29 (0.57–2.99) |
| P-trendb | 0.71 | 0.86 | 0.52 |
| Continuous lnBPAc | 1.05 (0.88–1.25) | 1.01 (0.80–1.26) | 1.14 (0.85–1.50) |
| Osmolality adjusted BPA (ng/mL) |
All chidren (N = 64/361) Adjusteda OR (CI 95%) |
Boys (N = 39/184) Adjusteda OR (CI 95%) |
Girls (N = 25/177) Adjusteda OR (CI 95%) |
| ADHD-score 5 years ≥ 90th percentile | |||
| 1st tertile (≤0.87) | Reference | Reference | Reference |
| 2nd tertile (0.88–1.96) | 0.92 (0.42–1.93) | 0.60 (0.21–1.69) | 1.78 (0.55–5.73) |
| 3rd tertile (≥ 1.97) | 1.33 (0.68–2.61) | 1.45 (0.61–3.45) | 1.29 (0.46–4.64) |
| p-trendb | 0.37 | 0.32 | 0.56 |
| Continuous lnBPAc | 1.17 (0.93–1.46) | 1.17 (0.88–1.56) | 1.25 (0.85–1.85) |
aAnalyses adjusted for maternal education, maternal age, pre-pregnancy BMI, child age at evaluation, parity. The sex-combined analyses were additionally adjusted for child sex
bTrend across tertiles tested by inserting the tertile osmolality adjusted BPA as an ordinal indicator variable (0,1,2)
cBPA inserted as a continuous variable transformed by the natural logarithm
* P-value < 0.05