Table 2. Genome edited NHPs.

Only mutant NHPs with relevant-phenotypes are shown. RTT: Rett Syndrome, PMS: Phelan-McDermid Syndrome, AHC-HH: Adrenal hypoplasia congenital and hypogonadotropic hypogonadism, ADPKD: Autosomal dominant polycystic kidney disease, PD: Parkinson’s disease, DMD: Duchenne muscular dystrophy, SCID: Severe combined immunodeficiency.

Diseases	Species	Genes	Mutations	Phenotypes	Refs
RTT	Cynomolgus	MECP2	KO TALEN	RTT-like symptoms in het females	[12]
PMS	Cynomolgus	SHANK3	KO CRISPR	PMS-like symptoms in homo and het monkeys	[24,26]
Longevity	Cynomolgus	SIRT6	KO CRISPR	Prenatal death, developmental retardation	[52]
Microcephaly	Cynomolgus	MCPH1	KO TALEN	Microcephaly	[73]
Circadian rhythm	Cynomolgus	BMAL1	KO CRISPR	Reduced sleep	[74]
AHC-HH	Cynomolgus	DAX1	KO CRISPR	AHC-HH-like symptoms	[75]
ADPKD	Cynomolgus	PKD1	KO CRISPR	Cysts formation in homo and het monkeys	[63]
PD	Rhesus	PINK1	KO CRISPR	Neurodegeneration	[76]
DMD	Rhesus	DMD	KO CRISPR	Muscular degeneration	[77]
Hypercholesterolemia	Rhesus	PCSK9	in vivo KO Meganuclease	Reduced serum cholesterol	[78]
SCID	Marmoset	IL2RG	KO ZFN/TALEN	Immunodeficiency	[9]