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. 2021 Mar 9;15:1075–1089. doi: 10.2147/DDDT.S275228

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© 2021 Bi et al.

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The effects of resveratrol on ASM cells proliferation and apoptosis. (A) HPLC chromatograms of resveratrol in Polygonum cuspidatum extraction. (B, C) ASM cells were treated with PDGF (10 ng/mL) and resveratrol (6.25 μM, 12.5 μM, 25 μM, 50 μM) at different concentrations alone or in combination for 24h and 48h. Cell proliferation was detected by CCK-8. The data were expressed as mean ± SD (n=6) of each group, ^ns P>0.05 vs PDGF group, ** P<0.01 vs PDGF group, ^#P<0.01vs DMSO group (control group). (D, E) The apoptosis of ASM cells were detected by Annexin-V staining after treatment with resveratrol (25 μM, 50 μM) for 48 h. The data were expressed as mean ± SD (n=3) of each group, ** P<0.01 vs DMSO group (control group).