Preparation and quantitative profiling of Tian-Huang formula, a mixed extract of Panax notoginseng and Coptis chinensis. (a) P. notoginseng root and rhizome, (b) C. chinensis root, (c) dry powder of Tian-Huang formula (THF), a mixed extract of P. notoginseng and C. chinensis, (d) chemical structure of eight main components of THF, namely, ginsenoside Rb1, ginsenoside Rg1, ginsenoside Rd, ginsenoside R1, notoginsenoside R1, coptisine, palmatine, and berberine, and (e) content of abovementioned eight components analyzed by HPLC following the method recorded by Pharmacopoeia of the People's Republic of China (2015).