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. 2021 Mar 6;2021:6617586. doi: 10.1155/2021/6617586

Figure 4.

Figure 4

Ingenuity pathways analysis suggested that THF improves the glucose intolerance and hepatosteatosis by regulating PI3K and LDL-R involved pathways. (a) Enrichment analysis performed using the pathway-associated metabolites sets with MetaboAnalyst 4.0. (b). Overview of pathway analysis using Fisher's Exact Test as algorithms with MetaboAnalyst 4.0; (i) phenylalanine, tyrosine, and tryptophan biosynthesis, (ii) valine, leucine, and isoleucine, (iii) alanine, aspartate, and glutamate metabolism, (iv) aminoacyl-tRNA biosynthesis, (v) phenylalanine metabolism, (vi) methane metabolism. (c) Top regulated metabolic network generated by IPA software (Qiagen, Germany) based on the different metabolites discovered through metabolomics analysis hinted that THF improves the glucose intolerance and hepatic steatosis by regulating PI3K and LDL involved pathways. PI3K, Phosphatidylinositol-3 kinase; LDL-R, low-density lipoprotein receptor. HFF, high-fat and high-fructose diets; THF, Tian-Huang formula, a mixed extract of P. notoginseng and C. chinensis.