Figure 6.

Schematic model summarizing the proposed underlying mechanisms of the THF ameliorates glucose intolerance and hepatosteatosis by maintaining the homeostasis of AKT- SREBP nexus in DIO rats. HFF, high-fat and high-fructose diets; THF, Tian-Huang formula, a mixed extract of P. notoginseng and C. chinensis; IRS1, insulin receptor substrate 1; PI3K, phosphatidylinositol-3 kinase; AKT, protein kinase B; SREBP-2, sterol regulatory element-binding protein-2; PCSK9, proprotein convertase subtilisin/kexin type 9; LDL-R, low-density lipoprotein receptor.