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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Gastroenterology. 2020 Sep 24;160(4):1208–1223.e4. doi: 10.1053/j.gastro.2020.09.030

Figure 4. Sympathetic input has region-specific effects on ascending and descending myenteric neuron circuits.

Figure 4.

(A) Diagram illustrating experimental setup. (B-C) Percentage of myenteric neurons in proximal (B) and distal (C) colon that responded to colon stimulation in isolated colon preparations (circles) and colon preparations with SPG intact (without external SPN activation; squares). (D-F) Percentage of neurons in proximal (D), middle (E), and distal (F) colon regions that responded to oral (i) or anal (ii) stimulation during and immediately following SPN stimulation. *p<0.05, **p<0.01; two-way ANOVA (B,C) and one-way ANOVA (D-F) with Tukey’s post hoc test for multiple comparisons.