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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Gastroenterology. 2020 Sep 24;160(4):1208–1223.e4. doi: 10.1053/j.gastro.2020.09.030

Figure 7. RNA sequencing of human interstitial cells provides molecular evidence that region-specific responses to sympathetic input exist in human colon.

Figure 7.

(A) T-SNE plot showing 1684 SIP syncytium nuclei from human colon; ICC, PDGFRA+, and smooth muscle cells (SMC) formed distinct clusters, identified using canonical markers (Supplementary Figure S7). (B-C) T-SNE and violin plots showing the adrenoceptor, ADRA1A, was highly expressed in PDGFRA+ cells, but not in other groups. (D-E) ADRA1A expression was significantly higher in right colon compared to sigmoid colon, despite no difference in PDGFRA. ***p< 0.0001; Wilcoxon rank sum test with Bonferroni correction (C,E).