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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Neurobiol Dis. 2021 Feb 1;152:105272. doi: 10.1016/j.nbd.2021.105272

Fig. 2.

Fig. 2.

Early activation of IFN-I signaling in microglia from 5×FAD mice. A. Volcano plot showing differences in gene expression in purified microglia from 3–4–month–old 5×FAD mice with respect to nonTg littermates. Unpaired two-way Student’s t-test. Significance is plotted against fold change. Up- or down- regulated genes are highlighted in red and green, respectively, with adjusted significance of P < 0.05. n = 3 per group. B. Top 20 significantly enriched Gene Ontology (GO) terms from genes differentially expressed in purified microglia from 3–4–month–old 5×FAD mice compared to nonTg littermates. The significance of the observed GO enrichment was estimated by the P value plotted on a log10 scale. n = 3 per group. C. Heat map showing clustering of upregulated and downregulated interferon stimulated genes (ISGs) expressed in purified microglia from 3–4–month–old nonTg and 5×FAD mice. The major upregulated and downregulated genes were listed. D&E. Venn diagram showing upregulated (D) and downregulated (E) interferon stimulated genes (ISGs) induced by Type I and/or Type II interferons in purified microglia from 3–4–month–old 5×FAD mice compared to nonTg littermates.