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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Invest Radiol. 2021 Apr 1;56(4):244–251. doi: 10.1097/RLI.0000000000000737

Figure 1. S. mansoni-infected mice develop severe liver fibrosis.

Figure 1.

Liver and spleens from naïve mice (n = 6) or WT mice infected with S. mansoni for 9–11 weeks (n = 8) were harvested (A) and weighed (B). Collagen content of the liver was assessed by hydroxyproline levels (C). Liver sections were stained with Sirius red (D) and collagen content was quantified by measuring the collagen proportional area (E). The arrow in D shows the presence of an egg trapped in a liver sinusoid and the concentric deposition of extracellular matrix. Giemsa-staining showing inflammatory infiltrate in infected animals (magnification = 10x) (F). The inserts show the presence of macrophages and eosinophils in S. mansoni-infected animals (magnification = 40x). Results are expressed as average ± SEM and the statistical significance was assessed by two-tailed Student’s t-test with Welch’s correction.