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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Invest Radiol. 2021 Apr 1;56(4):244–251. doi: 10.1097/RLI.0000000000000737

Figure 2. Molecular imaging of Type I collagen and allysine detect liver fibrosis in S. mansoni-infected mice.

Figure 2.

Representative images of EP-3533 signal enhancement at 15 minutes post probe injection in naïve and infected mice (A). T1-weighed gradient echo sequences were performed pre and 20 min post EP-3533 injection in naïve (n = 5) or infected WT (n = 8) mice to determine changes in contrast to noise ratio (ΔCNR) (B). The values of ΔCNR for EP-3533 directly correlates to the hydroxyproline content in infected animals (C). Representative images of Gd-Hyd signal enhancement at 15 minutes post probe injection in naïve and infected WT mice (D). T1-weighed gradient echo sequences were also performed pre and 15 min post Gd-Hyd injection in naïve or infected mice to determine ΔCNR (E). The values of ΔCNR for Gd-Hyd directly correlates to the hydroxyproline content in infected animals (F). Pearson correlation coefficient (r) was calculated for (C) and (F). Other results are expressed as average ± SEM and the statistical significance was assessed by two-tailed Student’s t-test with Welch’s correction.