Table 1:
Characteristics of entire cohort by drug exposure class
| Variable | Overall (n=1490) | None (n=379) | Biologics * (n=642) | Thiopurine# (n=242) | Combination** (n=227) | p |
|---|---|---|---|---|---|---|
| Maternal Age at Delivery in Years [mean (SD)] | 32.0 (4.6) | 32.5 (4.6) | 31.8 (4.5) | 31.9 (4.7) | 31.6 (4.5) | 0.07 |
| Total Pregnancies, including current [mean (SD)] | 2.1 (13) | 2.2 (1.3) | 2.1 (1.3) | 2.1 (1.4) | 2.0 (1.2) | 0.18 |
| Disease Duration [median years (IQR)] | 8.3 (4.4, 13.0) | 7.1(2.9, 12.6) | 8.7 (4.8, 13.3) | 8.5 (4.7, 12.4) | 8.7 (5.4, 13.6) | 0.001 |
| Body Mass Index^ [mean (SD)] | 24.9 (4.8) | 24.9 (4.3) | 25.0 (4.9) | 24.2 (4.5) | 25.2 (5.1) | 0.46 |
| Disease Status n (%) Crohn’s disease Ulcerative colitis IBD-unclassified | 921 (62%) 535 (36%) 34 (2%) |
147 (39%) 218 (58%) 14 (4%) |
471 (74%) 137 (23%) 8 (1%) |
137 (57) 98 (40) 7 (3) |
123 (71) 47 (27) 3 (2) |
<0.001 |
| Smoking Status n (%) Current Former (prior to pregnancy) Never | 23 (2%) 308 (22%) 1,057 (76%) |
4 (1%) 75 (21%) 272 (77%) |
11 (2%) 137 (23%) 451 (75%) |
5 (2%) 57 (25%) 163 (72%) |
3 (1%) 38 (18%) 169 (80%) |
0.53 |
| Alcohol Use n (%) Current Former (prior to pregnancy) Never | 146 (11%) 855 (62%) 384 (28%) |
28 (8%) 220 (63%) 103 (29%) |
59 (10%) 381 (64%) 156 (26%) |
22 (10%) 139 (61%) 65 (29%) |
37 (18%) 115 (55%) 57 (27%) |
0.02 |
| Recreationa 1 Drug Use n (%) Current Former (prior to pregnancy) Never | 1 (0.1%) 65 (5%) 1,321 (95%) |
1 (0.3%) 22 (6%) 327 (93%) |
0 (0%) 26 (4%) 573 (96%) |
0 (0%) 10 (4%) 216 (96%) |
0 (0%) 7 (3%) 202 (97%) |
0.42 |
*
Biologics defined as anti-TNF, anti-integrin, anti-IL 12/23
#
Thiopurine (azathioprine or 6-mercaptopurine)
**
Combination defined as biologic + thiopurine
^
Pre-pregnancy BMI as reported at intake