Table 2.
Effects of 24 h, 48 h, and 6 days exposures to TCS on IL-1β secretion from monocyte-depleted PBMCs.
| 24 h | IL-1β secretion in pg/mL (mean±S.D.) | |||
|---|---|---|---|---|
| [TCS]μM | F390 | F392 | F406 | F451 |
| 0 | 1254±93 | 923±126 | 2107±181 | 4967±136 |
| 0.05 | 1400±43+ | 1651±130+ | 2293±39+ | 3728±323* |
| 0.1 | 1305±36 | 1638±282+ | 2844±111+ | 2425±578* |
| 0.25 | 1288±113 | 1561±146+ | 2537±23 | 3828±1323 |
| 0.5 | 1325±54 | 1704±200+ | 2778±144+ | 4587±748 |
| 1 | 1393±77 | 1535±86+ | 2789±128+ | 4121±971 |
| 2.5 | 1480±65+ | 2120±149+ | 3274±90+ | 4937±473 |
| 5 | 2040±164+ | 4944±488+ | 5630±145+ | 7604±256+ |
| 48 h | IL-1β secretion in pg/mL (mean±S.D.) | |||
| [TCS]μM | F390 | F392 | F406 | F451 |
| 0 | 1357±55 | 778±138 | 1931±255 | 2761±218 |
| 0.05 | 1251±55 | 1126±34+ | 2303±232 | 3657±168+ |
| 0.1 | 1500±94 | 935±68 | 1903±80 | 3209±461 |
| 0.25 | 1563±94+ | 974±24 | 2531±58+ | 3389±340 |
| 0.5 | 1529±14+ | 1206±75+ | 3134±354 | 3185±220 |
| 1 | 1307±78 | 1187±32+ | 2638±435 | 3428±1006 |
| 2.5 | 1687±180 | 1762±170+ | 3415±39+ | 3551±775 |
| 5 | 3183±246+ | 3971±420+ | 5520±200+ | 4226±224+ |
| 6 d | IL-1β secretion in pg/mL (mean±S.D.) | |||
| [TCS]μM | F390 | F392 | F406 | F451 |
| 0 | 464±59 | 458±9 | 1746±64 | 67±12 |
| 0.05 | 428±58 | 637±14+ | 2122±110+ | 42±20 |
| 0.1 | 457±13 | 647±4+ | 2279±76+ | 30±17* |
| 0.25 | 471±7 | 649±6+ | 2025±73+ | 46±11 |
| 0.5 | 494±21 | 646±6+ | 2169±52+ | 38±10* |
| 1 | 525±15 | 731±6+ | 2443±100+ | 41±9* |
| 2.5 | 564±46 | 980±49+ | 2704±224+ | 31±7* |
| 5 | 833±112+ | 1272±17+ | 4791±378+ | 41±1 |
Values are mean±S.D. of triplicate determinations.
+
indicates a significant increases and
*
indicates a significant decrease in secretion compared to control cells, p<0.05