Table 3.
24 h | IL-1β secretion in pg/mL (mean±S.D.) | |||
---|---|---|---|---|
[TCS]μM | F214 | F217 | F224 | F238 |
0 | 545±35 | 5347±218 | 1906±143 | 287±7 |
0.05 | 781±100 | 7278±397+ | 1215±21* | 405±22+ |
0.1 | 519±43 | 19828±817+ | 1642±55 | 392±25+ |
0.25 | 581±31 | 6964±204+ | 1676±13 | 312±39 |
0.5 | 905±89+ | 6364±446+ | 1734±135 | 460±32+ |
1 | 623±27+ | 6240±94+ | 2043±290 | 409±44 |
2.5 | 1238±49+ | 2146±148* | 2306±192+ | 650±57+ |
5 | 5999±46+ | 7703±1341 | 9492±262+ | 7202±822+ |
48 h | IL-1β secretion in pg/mL (mean±S.D.) | |||
[TCS]μM | F214 | F217 | F224 | F238 |
0 | 349±41 | 6992±466 | 1652±62 | 179±49 |
0.05 | 1086±32+ | 10864±394+ | 2099±57+ | 201±65 |
0.1 | 596±69+ | 7174±347 | 2041±79+ | 118±19 |
0.25 | 387±30 | 8250±559+ | 2562±73+ | 190±116 |
0.5 | 314±8 | 8826±164+ | 2354±21+ | 170±7 |
1 | 362±28 | 8159±186+ | 2000±32+ | 285±20+ |
2.5 | 840±85+ | 8311±447+ | 3347±35+ | 321±64+ |
5 | 5773±281+ | 22401±1589+ | 4531±76+ | 6005±144+ |
6 d | IL-1β secretion in pg/mL (mean±S.D.) | |||
[TCS]μM | F214 | F217 | F224 | F238 |
0 | 261±36 | 7387±278 | 1679±10 | 353±134 |
0.05 | 949±60+ | 5286±55* | 1614±41 | 281±46 |
0.1 | 1228±143+ | 6503±63* | 1758±14+ | 258±6 |
0.25 | 571±63+ | 6684±174* | 2129±52+ | 463±29 |
0.5 | 975±154+ | 7510±616 | 1584±11+ | 208±28 |
1 | 601±146+ | 6445±906 | 2364±14+ | 216±20 |
2.5 | 1228±71+ | 8401±618 | 2638±80+ | 447±43 |
5 | 7881±138+ | 9735±961+ | 4771±24+ | 4056±134+ |
Values are mean±S.D. of triplicate determinations.
indicates a significant increase and
indicates a significant decrease in secretion compared to control cells, p<0.05