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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Environ Toxicol Pharmacol. 2021 Jan 28;83:103599. doi: 10.1016/j.etap.2021.103599

Table 3.

Effects of 24 h, 48 h, and 6 days exposures to TCS on IL-1β secretion from PBMCs.

24 h IL-1β secretion in pg/mL (mean±S.D.)

[TCS]μM F214 F217 F224 F238
0 545±35 5347±218 1906±143 287±7
0.05 781±100 7278±397+ 1215±21* 405±22+
0.1 519±43 19828±817+ 1642±55 392±25+
0.25 581±31 6964±204+ 1676±13 312±39
0.5 905±89+ 6364±446+ 1734±135 460±32+
1 623±27+ 6240±94+ 2043±290 409±44
2.5 1238±49+ 2146±148* 2306±192+ 650±57+
5 5999±46+ 7703±1341 9492±262+ 7202±822+

48 h IL-1β secretion in pg/mL (mean±S.D.)

[TCS]μM F214 F217 F224 F238
0 349±41 6992±466 1652±62 179±49
0.05 1086±32+ 10864±394+ 2099±57+ 201±65
0.1 596±69+ 7174±347 2041±79+ 118±19
0.25 387±30 8250±559+ 2562±73+ 190±116
0.5 314±8 8826±164+ 2354±21+ 170±7
1 362±28 8159±186+ 2000±32+ 285±20+
2.5 840±85+ 8311±447+ 3347±35+ 321±64+
5 5773±281+ 22401±1589+ 4531±76+ 6005±144+

6 d IL-1β secretion in pg/mL (mean±S.D.)

[TCS]μM F214 F217 F224 F238
0 261±36 7387±278 1679±10 353±134
0.05 949±60+ 5286±55* 1614±41 281±46
0.1 1228±143+ 6503±63* 1758±14+ 258±6
0.25 571±63+ 6684±174* 2129±52+ 463±29
0.5 975±154+ 7510±616 1584±11+ 208±28
1 601±146+ 6445±906 2364±14+ 216±20
2.5 1228±71+ 8401±618 2638±80+ 447±43
5 7881±138+ 9735±961+ 4771±24+ 4056±134+

Values are mean±S.D. of triplicate determinations.

+

indicates a significant increase and

*

indicates a significant decrease in secretion compared to control cells, p<0.05