Table 4.
Effects of 24 h, 48 h, and 6 days exposures to TCS on IL-6 secretion from NK cells.
| 24 h | IL-6 secretion in pg/mL (mean±S.D.) | ||
|---|---|---|---|
| [TCS] μM | F461 | F467 | F475 |
| 0 | 45142±470 | 22028±246 | 6449±153 |
| 0.05 | 24767±331* | 32043±605+ | 8652±372+ |
| 0.1 | 16906±419* | 25966±1263+ | 11145±262+ |
| 0.25 | 13156±146* | 24198±512+ | 8260±304+ |
| 0.5 | 22128±359* | 23609±372+ | 6623±240 |
| 1 | 33961±296* | 22710±619 | 6087±272 |
| 2.5 | 38419±569* | 13625±775* | 4957±115* |
| 5 | 37767±150* | 2679±827* | 435±314* |
| 48 h | IL-6 secretion in pg/mL (mean±S.D.) | ||
| [TCS] μM | F461 | F467 | F475 |
| 0 | 18325±260 | 27302±55 | 14486±265 |
| 0.05 | 25728±182+ | 27206±620 | 20787±324+ |
| 0.1 | 18381±188 | 28095±579 | 19835±442+ |
| 0.25 | 35144±237+ | 32063±715+ | 16803±1334 |
| 0.5 | 21992±182+ | 28476±719 | 21533±333+ |
| 1 | 21881±307+ | 25206±721* | 15343±126+ |
| 2.5 | 40228±251+ | 24984±810* | 7232±396* |
| 5 | 4630.6±87* | 2000±330* | 2882.5±306* |
| 6 d | IL-6 secretion in pg/mL (mean±S.D.) | ||
| [TCS] μM | F461 | F467 | F475 |
| 0 | 49128±105 | 44379±1221 | 24840±180 |
| 0.05 | 55489±120+ | 39621±784* | 29062±238+ |
| 0.1 | 48072±120* | 43258±1172 | 28744±552+ |
| 0.25 | 49906±501 | 47288±367+ | 26998±810+ |
| 0.5 | 44614±296* | 41894±548 | 27649±385+ |
| 1 | 47961±457* | 44712±1617 | 24538±378 |
| 2.5 | 44919±158* | 37561±1667* | 15094±120* |
| 5 | 44961±105* | 8651.5±533* | 12157±390* |
Values are mean±S.D. of triplicate determinations.
+
indicates a significant increase and
*
indicates a significant decreases in secretion compared to control cells, p<0.05