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Idasanutlin concentration-dependently activates p53 in human macrophages. (A) Western analysis and quantification of p53 and CDKN1A (p21) protein expression in macrophages exposed to indicated concentrations of RG7388 for 24 h (n = 4). (B) mRNA expression of indicated p53 target genes in macrophages treated with different concentrations of RG7388 for 24 h (n = 3).
