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. 2021 Feb 25;13(5):958. doi: 10.3390/cancers13050958

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Idasanutlin inhibits expression of CD14, TLR7, and TLR8, attenuating inflammatory response to R848. (A) Western analysis and quantification of IκB and JNK phosphorylation in macrophages following differentiation in the presence of 250 nM RG7388 and treatments with 0.1 and 100 ng/mL LPS (n = 6). (B,C) mRNA expression of indicated genes (B, n = 5) and CD14 cell surface expression (C, n = 4) in macrophages differentiated with M-CSF in the presence of 250 nM RG7388 for 7 days. (D,E) mRNA expression of indicated genes (D) and Western blot analysis and quantification of IκB and JNK phosphorylation (E) in macrophages following differentiation in the presence of 250 nM RG7388 and treatments with 0.1 and 1 µg/mL R848 (n = 4).