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Plasma CD73 activity. CD73 metabolizes AMP to adenosine, and the ratio of AMP to adenosine concentration is an indicator of CD73 enzymatic activity. Plasma was obtained from cd73−/−/apoE−/− and apoE−/− mice at 12 and 32 weeks. ApoE−/− mice were found to have reduced AMP/adenosine concentration ratios, as measured by HPLC, when compared with cd73−/−/apoE−/− mice. p < 0.001 using ANOVA.
