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Schematic diagrams illustrating the PBPK model for mPEG-PCL NPs, including mononuclear phagocytic system in organs represented as “MPS” and enhanced permeability and retention in tumours represented as “EPR.” Arrows indicate the direction of transport of mPEG-PCL NPs, while grey boxes indicate the uptake of mPEG-PCL NPs by MPS or EPR from blood circulation or tissues.
