Figure 1.

Generation of cytarabine resistant cell lines. (A) Acute myeloid leukemia (AML) cell lines stably resistant to cytarabine (AraC-Res) were generated by culturing AML cell lines under gradually increasing doses of AraC for up to a year (~6–10 times increase in AraC dose). (B–E) Cell viability of all cell line pairs upon treatment with a dose range of AraC as measured by MTS assays after 72 h of incubation (at least n = 5). Significance was tested using students’ t-test. p values are indicated as: **** p < 0.0001, *** p < 0.001, ** p < 0.01, and * p < 0.05.