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. 2021 Feb 26;22(5):2337. doi: 10.3390/ijms22052337

Figure 4.

Figure 4

The autophagy inhibitor chloroquine (CQ) increases the efficacy of AraC in parental cells, but does not re-sensitize AraC-resistant cells for AraC. (A–D) Cell viability (MTS assays) of HL-60, MOLM-13, THP-1, and U-937 cell line pairs upon treatment with a concentration range of CQ (72 h, n = 3). (E–H) Parental HL-60, MOLM-13, THP-1, and U-937 cells were treated for 72 h with various concentrations of CQ in combination with a sublethal dose of AraC. Cell viability was measured using MTS assays after 72 h of incubation (at least n = 3) (I–L) As in (E–H) but using the AraC-Res cell lines. Of note, CQ was pre-incubated for 1 h before adding AraC. Significance was tested using student’s t-test. p values are indicated as: ** p < 0.01, and * p < 0.05.