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Pathway of prostanoid synthesis and their respective receptors. Phospholipase A2 (PLA2) facilitates arachidonic acid production by acting on membrane phospholipids. Arachidonic acid is converted to many different prostanoids (PGE2, Thromboxane A2, PGI2, PGF2α and PGD2) via the COX-1 and COX-2 enzymes. These prostaglandins then mediate their functions through respective receptors. Figure adapted from Majumder et al., (2018) [53].
