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. 2021 Feb 24;13(5):942. doi: 10.3390/cancers13050942

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Designing a humanized mouse model using umbilical cord blood cells (A). These cells are introduced into a healthy immunodeficient mouse (B), so that it will develop human immune cells. Human xenografts from triple-negative breast cancer (TNBC) patients can be obtained (C) and transplanted (D) into the mouse model at the mammary site. The goal is for the mouse to develop TNBC (E) so that it is possible to observe an interaction between human cancer cells and human lymphocytes in this model.