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Structure of polymeric immunoglobulin receptor (pIgR). The pIgR contains an intracellular portion, a transmembrane portion and an extracellular portion. The extracellular portion has six domains. Extracellular domains 1 to 5 (D1–D5) are five tandem immunoglobulin-like domains that are involved in binding to Ig polymers. The extracellular domain 6 (D6) contains a site for proteolytic cleavage.
