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. 2021 Feb 26;22(5):2350. doi: 10.3390/ijms22052350

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Main medications against NAFLD and its advanced forms and their mechanisms of action. See text for details. Note: Blue lines correspond to signal activation; red lines correspond to signal block. Abbreviations: ASK-1, apoptosis signal-regulating kinase-1; FFA, free fatty acids; FXR, farnesoid X receptor; GLP-1 RAs, glucagon-like peptide-1 receptor agonists; LOXL-2, lysyl oxidase-like 2; OCA, obeticholic acid; PPAR, peroxisome proliferator activated receptor; SGLT-2, sodium-glucose co-transporter-2; THR, thyroid hormone receptor.