Skip to main content
. 2021 Feb 24;13(5):941. doi: 10.3390/cancers13050941

Figure 1.

Figure 1

Gene expression and correlation analysis of PDHK1 and genes involved in glucose metabolism in non-small cell lung cancer (NSCLC) tumors. The expression level of selected genes was investigated in two individual transcriptomic NSCLC cohorts. (A) PDHK1 RNA sequencing data from the cancer genome atlas (TCGA) (n = 110 adjacent normal tissue sample, n = 1016 LUAD or LUSC samples) in the total cohort, and in EGFR wild-type (EGFRwt) and EGFRmutated (EGFRmut) samples, and (B) PDHK1 mRNA microarray data from paired samples from GSE18842 (n = 44 adjacent normal tissue samples and n = 46 LUAD or LUSC samples). (C) Relative expression (FPKM log2 fold change) for a panel of genes involved in glucose metabolism. (D) Correlation analysis (Spearman Rho values) between PDHK1 and the panel of genes involved in glucose metabolism. Correlation analysis (Spearman Rho values) of (E) PDHK to c-MYC, (F) NRAS and (G) CAIX and CAXII. p values are presented for all the included data in Supplementary Table S1. Unpaired two-tailed t-test was used for (A) **** p < 0.0001.