Table 2.
Clinical presentation.
| Male n = 6853 (56.8) |
Female n = 5210 (43.2) |
Total n = 12,063 |
p-Value | |
|---|---|---|---|---|
| Symptoms | ||||
| Dry cough, n (%) | 3996 (58.5) | 3011 (58.1) | 7007 (58.3) | <0.001 |
| Productive cough, n (%) | 1152 (16.9) | 723 (13.9) | 1875 (15.6) | |
| Fever > 38°, n (%) | 4650 (68.1) | 2976 (57.4) | 7626 (63.5) | <0.001 |
| Ageusia, n (%) | 414 (6.2) | 381 (7.6) | 795 (6.8) | 0.005 |
| Anorexia, n (%) | 1267 (18.9) | 1063 (20.9) | 2330 (19.8) | 0.008 |
| Headache, n (%) | 729 (10.8) | 635 (12.4) | 1364 (11.5) | 0.007 |
| Diarrhea, n (%) | 1473 (21.7) | 1285 (24.9) | 2758 (23.1) | <0.001 |
| General malaise, n (%) | 663 (9.9) | 805 (15.9) | 1468 (12.5) | <0.001 |
| Vomiting, n (%) | 377 (5.6) | 506 (9.9) | 883 (7.4) | <0.001 |
| Abdominal pain, n (%) | 376 (5.6) | 402 (7.8) | 778 (6.5) | <0.001 |
| Arthralgia, n (%) | 2043 (30.2) | 1610 (31.5) | 3653 (30.8) | 0.158 |
| Anosmia, n (%) | 385 (5.8) | 331 (6.6) | 716 (6.1) | 0.089 |
| Asthenia, n (%) | 2878 (42.7) | 2266 (44.4) | 5144 (43.4) | 0.072 |
| Odynophagia, n (%) | 631 (9.4) | 531 (10.4) | 1162 (9.8) | 0.062 |
| Dyspnea, n (%) | 3971 (58.2) | 2960 (57.2) | 6931 (57.8) | 0.265 |
| Physical Examination | ||||
| Confusion, n (%) | 713 (10.6) | 702 (13.7) | 1415 (11.9) | <0.001 |
| Tachypnea, n (%) | 2173 (32.6) | 1505 (29.8) | 3678 (31.4) | 0.002 |
| Hypotension (SBP < 100 mmHg), n (%) | 358 (5.5) | 331 (6.7) | 689 (6.0) | 0.006 |
| Tachycardia (>100 bpm), n (%) | 1502 (22.8) | 1075 (21.5) | 2577 (22.2) | 0.103 |
| Oxygen saturation < 92%, n (%) | 2363 (35.6) | 1569 (31.1) | 3932 (33.6) | <0.001 |
| Wheezing, n (%) | 355 (5.3) | 359 (7.1) | 714 (6.1) | <0.001 |
| Rales, n (%) | 757 (11.4) | 517 (10.2) | 1274 (10.9) | 0.045 |
| Crackles, n (%) | 3504 (52.8) | 2648 (52.4) | 6157 (52.7) | 0.666 |
| Radiological Data | ||||
| Unilateral condensation, n (%) Bilateral condensation, n (%) |
1224 (18.0) 2158 (31.8) |
885 (17.3) 1526 (29.9) |
2109 (17.7) 3684 (31.0) |
0.071 0.007 |
| Unilateral interstitial infiltrates, n (%) Bilateral interstitial infiltrates, n (%) |
700 (10.3) 3647 (53.7) |
547 (10.7) 2481 (48.6) |
1247 (10.5) 6128 (51.5) |
0.194 <0.001 |
| Unilateral pleural effusion, n (%) Bilateral pleural effusion, n (%) |
192 (2.8) 89 (1.3) |
152 (3.0) 96 (1.9) |
344 (2.9) 185 (1.6) |
0.587 0.012 |
| Radiological worsening *, n (%) | 2255 (43.6) | 1343 (35.9) | 3598 (40.4) | <0.001 |
| Laboratory Data | ||||
| Lymphocytes < 1500/mm3, n (%) | 5771 (84.8) | 4101 (79.9) | 9872 (82.7) | <0.001 |
| LDH > 300 IU/L, n (%) | 3377 (56.9) | 2255 (51.1) | 5632 (54.4) | <0.001 |
| D-Dimer > 500 ng/mL, n (%) | 3148 (59.7) | 2417 (61.5) | 5565 (60.4) | 0.084 |
* Radiological worsening at follow-up at 7 days, discharge, or death. LDH: lactate dehydrogenase; SBP: systolic blood pressure. bpm: beats per min. mmHg: millimeters of mercury.