Table 4.

NSMP subgroups by β-catenin and ARID1A alterations. Values are counts (percentages) or mean ± standard deviation [interquartile range].

Clinicopathologic Characteristics	β-Catenin Abnormal Subgroup (n = 16; 32,7%)			NSMP Subgroup (n = 33; 67,3%)
	β-CATabn	β-CATabn_A	p-Value	NSMP	NSMP_A	p-Value
	(n = 9)	(n = 7)		(n = 14)	(n = 19)
Age, years	49 ± 13	61 ± 10	0.044	66 ± 10	62 ± 7	0.352
	[40–54]	[55–73]		[55–75]	[58–69]
Body mass index, kg/m2	27.3 ± 7.8	31.1 ± 4.7	0.186	27.6 ± 6.1	31.3 ± 9.5	0.229
	[20.3–29.1]	[28.1–33.8]		[23.4–28.9]	[24.2–37.3]
Tumor type			0.175			1.000
Endometrioid	9 (100)	5 (71)		13 (93)	18 (95)
Dedifferentiated/Undifferentiated	0 (0)	2 (29)		1 (7)	1 (5)
Heterogeneity	1 (11)	4 (57)	0.106	2 (14)	7 (37)	0.241
Grade			0.001			0.391
1	8 (89)	0 (0)		8 (57)	6 (32)
2	1 (11)	4 (57)		4 (29)	9 (47)
3	0 (0)	3 (43)		2 (14)	4 (21)
Depth of invasion ≥50%	0 (0)	3 (43)	0.062	3 (21)	4 (21)	1.000
LVSI	0 (0)	3 (43)	0.062	2 (14)	5 (26)	0.670
Lymph node status			0.437			0.830
Negative	9 (100)	6 (86)		12 (86)	14 (74)
Positive	0 (0)	1 (14)		1 (7)	3 (16)
Unknown/Not tested	0 (0)	0 (0)		1 (7)	2 (11)
FIGO stage			0.758			1.000
IA	7 (78)	4 (57)		10 (71)	14 (74)
IB/II	1 (11)	2 (29)		2 (14)	2 (11)
III	1 (11)	1 (14)		2 (14)	3 (16)
Extensive necrosis	0 (0)	4 (57)	0.019	6 (43)	9 (47)	1.000
MELF	2 (22)	2 (29)	1.000	3 (21)	7 (37)	0.455
Tumor budding	0 (0)	4 (57)	0.019	3 (21)	7 (37)	0.455
High sTILs	1 (11)	6 (86)	0.009	7 (50)	12 (63)	0.497
High iTILs	0 (0)	4 (57)	0.019	6 (43)	13 (68)	0.173
Mitoses/10 HPF	9.3 ± 4.8	57.7 ± 26.3	0.001	31.1 ± 33.7	37.2 ± 21.0	0.100
	[5–10]	[42–80]		[10–40]	[24–50]
Ki67 proliferative index	20.7 ± 11.2	55.4 ± 14.5	0.003	31.4 ± 18.8	41.5 ± 13.5	0.037
	[13.8–29.6]	[49.5–64.8]		[19.3–36.9]	[33.7–42.7]