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. 2021 Feb 26;22(5):2333. doi: 10.3390/ijms22052333

Figure 2.

Figure 2

Microgravity regulates the expression of arginase I. Microgravity up-regulates the expression of arginase I through p38 MAPK-C/EBPβ pathway. The unknown protein (indicated as “?”) senses microgravity and transmits the signal to p38 MAPK, thus causing a series of cascade conduction (as shown in the blue part). The gray part (as shown on the left) indicates the signal pathway of IL-4 stimulated cells under normal gravity. IL-4R, interleukin-4 receptor; JAK, Janus kinase; YM1, Chitinase-like protein.