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. 2021 Feb 26;13(5):977. doi: 10.3390/cancers13050977

Table 3.

Examples of lncRNAs implicated in glucose metabolism alteration in female reproductive system cancers.

lncRNA Deregulation Functions and Targets Reference
NRCP Upregulated in ovarian cancers Acts as an intermediate binder between STAT1 and RNA polymerase II; increases the expression of glucose-6-phosphate isomerase (GPI), aldolase A (ALDOA) and aldolase C (ALDOC) [84]
GHET1 Upregulated in ovarian cancers Interacts with the E3 ubiquitin ligase von Hippel-Lindau (VHL); prevents VHL-mediated HIF1α-degradation; promotes glucose uptake and lactate production [27]
H19 Upregulated in ginsenoside 20(S)-Rg3-treated ovarian cancers Sponges miR-324-5p; upregulates PKM2; increases glucose uptake and lactate production [34]
UCA1 Upregulated in radioresistant cervical cancer Upregulates HK2 [85]