Table 5.
Examples of lncRNAs implicated in glucose metabolism alteration in hematologic cancer.
| lncRNA | Deregulation | Functions and Targets | Reference |
|---|---|---|---|
| ANRIL | Upregulated in acute myeloid leukemia (AML) | Increases the expression of GLUT-1 and LDAH, upregulates AdipoR1, AMPK and SIRT1 | [90] |
| LINP1 | Upregulated in AML | Increases the expression of GLUT-1 and LDHA; upregulates HNF4α; activates the AMPK/WNT5A signaling pathway | [92] |
| UCA1 | Upregulated in AML | ceRNA of miR-125a; upregulates HK2; blocks HIF1α-dependent glycolysis | [32] |
| HOTAIRM1 | Upregulated in AML | Activates the Wnt/β-catenin pathway; enhances glucose uptake and lactate production | [33] |
| PDIA3P | Upregulated in multiple myeloma | Interacts with c-MYC; upregulates G6PD expression and PPP flux | [97] |
| MALAT1 | Upregulated in multiple myeloma | Targets miR-1271-5p; increases SOX13 expression | [98] |