Figure 2.

Specificity of DDX11 and FANCJ DNA helicases towards a set of G4-containing DNA substrates, whose structure is schematically depicted. The sequence of the corresponding synthetic oligonucleotides is also reported. Guanine residues forming the stacked G-quartets (colored in blue in the drawings) are highlighted in bold and in blue and underlined. Different catalytic efficiency of DDX11 and FANCJ in resolving the G4 DNA substrates is roughly indicated by a variable number of +, according to previous reports [6,7]. NA: not active.