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. 2021 Feb 24;13(5):936. doi: 10.3390/cancers13050936

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pathology and quantitative immunolabeling characterization of irradiation effects at 12 months after irradiation of normal rats. (A–I) No histopathologic alterations were seen in collateral areas where the deposited dose was subdivided in single-beam trajectories (5 Gy BB2, 5/376 Gy MRT2 valley/peak dose, 2/137 Gy MRT5 valley/peak dose), for (A) H&E staining, (B) Collagen−4, RECA-1, Glut-1 immunolabeling, (C) CD68 reactivity, (D) Olig2 staining, and (E) NeuN-GFAP dual-labeling. The same results between groups were obtained for quantitative analysis of (F) total cell density and (G) number of blood vessels, while (H) the density of CD68-positive cells moderately increased after multiport MRT. In contrast, the same (I) oligodendrocyte and (J) neuronal densities were found in all groups.