Table 2.
Regenerative medicine mentioned in this review
| Supplementation Therapy with Exogenous Cytokines | |||
|---|---|---|---|
| Method | Clinical Significance | Literature | |
| hepatocyte growth factor (HGF) | nonviral liposome-mediated gene transfer | Improvement in nerve conduction velocity | [66] |
| basic fibroblast growth facto (bFGF) | intramuscular injection of recombinant bFGF protein | Improvement in the motor nerve conduction velocity of the sciatic nerve and in sciatic nerve blood flow | [67] |
| nerve growth factor (NGF) | recombinant protein | Improvement of thermal allodynia in streptozotocin-induced diabetic rats. | [56] |
| placental growth factor 2 (PLGF-2) | intramuscular gene transfer of plasmid DNA by electroporation | Improved hypoalgesia in diabetic mice Restoration sensory nerve function |
[72] |
| Cell transplantation therapy | |||
| cell source | Clinical Significance | Literature | |
| mononuclear cells | bone marrow | Improvement of mechanical hyperalgesia and cold allodynia in streptozotocin-induced diabetic rats. Improvement in sciatic motor nerve conduction velocity, sensory nerve conduction velocity |
[73] |
| mesenchymal stem cells | bone marrow | Improvement of mechanical hyperalgesia in streptozotocin-induced diabetic rats. Restoration of nerve conduction velocity and sciatic nerve blood flow | [74] |
| endothelial progenitor cells | umbilical cord blood | Improvement in sciatic motor nerve conduction velocity and sciatic nerve blood flow | [75] |
| Exosome | |||
| exosome source | Clinical Significance | Literature | |
| Schwann cell-derived exosomes | Schwann cell | Improvement in sciatic nerve conduction velocity and increasing thermal and mechanical sensitivity in diabetic mouse | [78] |
| Mesenchymal stromal cell-derived exosomes | bone marrow | Improvement of thermal and mechanical sensitivity in diabetic mouses. Improvement in sciatic motor nerve conduction velocity, sensory nerve conduction velocity |
[79] |