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. 2021 Feb 25;22(5):2298. doi: 10.3390/ijms22052298

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schema outlining the renin-angiotensin-aldosterone system cascade including the renal effects of receptor stimulation. AGT, angiotensinogen; ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2; ANG, angiotensin; ANG I, angiotensin I; ANG II, angiotensin II; ANG III, ANG-(2–8); ANG IV, ANG-(3–8); APA, aminopeptidase A; APN, aminopeptidase N; AT1R, angiotensin II type 1 receptor; AT2R, angiotensin II receptor; MAS, angiotensin-(1–7) receptor MAS; MR, mineralocorticoid receptor; NEP, neutral endopeptidase; PEP, prolyl endopeptidase; PRR, (Pro)renin- receptor.